Kirkman Labs: TMG (Trimethylglycine) - 500mg with Folate & Methyl B12 - 120 Capsules

Trimethylglycine (TMG) is an important cofactor in methylation, a process that occurs in every cell in the body to synthesize and donate methyl groups for other processes in the body.

Methylation is the process of adding methyl groups to a molecule. A ‘methyl group’ is a chemical structure made of one carbon and three hydrogen atoms.

TMG can donate one of its methyl groups to homocysteine which turns homocysteine back into methionine and prevents homocysteine levels from getting too high. Additionally, by donating a methyl group, it helps produce S-adenosylmethionine (SAMe), which can help maintain healthy serotonin levels in the body that support mood, energy, concentration and a feeling of well-being. In the methylation cycle, SAMe is converted to homocysteine which aids in the production of glutathione. Glutathione is a powerful contributor to detoxifying the body and deterring oxidative stress.

The folate cycle, which consists of vitamin Bs, prompt the methylation cycle. Folate intake and levels in the body must be adequate for TMG to work biochemically. In some individuals, the use of natural folinic acid may be more beneficial than folic acid because folinic acid already has attached four hydrogen atoms and one methyl group, thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis. This product includes folinic acid and methyl B-12 because folic acid can mask the lack of adequate vitamin B-12.

TMG is a more active “methyl donor” than dimethylglycine (DMG) because it has an additional methyl group in its chemical structure. TMG is found in a variety of plant and animal sources. The TMG used in this product comes from beets.